中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (11): 810-814.

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

Telomerase expression in the glial scar of rats with spinal cord injury

  

  • 收稿日期:2011-12-27 修回日期:2012-03-15 出版日期:2012-04-15 发布日期:2012-04-15

Telomerase expression in the glial scar of rats with spinal cord injury

Mingkun Yang1, Weibin Sheng1, Tao Xu1, Kai Huang1, Yanjiao Wang2   

  1. 1  Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
    2  Department of Molecular Biology, Basic Medical College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Received:2011-12-27 Revised:2012-03-15 Online:2012-04-15 Published:2012-04-15
  • Contact: Weibin Sheng, M.D., Chief physician, Professor, Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China wbsheng@vip.sina.com
  • About author:Mingkun Yang★, Studying for master’s degree, Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China

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Abstract:

A rat model of spinal cord injury was established using the weight drop method. A cavity formed 14 days following spinal cord injury, and compact scar tissue formed by 56 days. Enzyme-linked immunosorbent assay and polymerase chain reaction enzyme-linked immunosorbent assay results demonstrated that glial fibrillary acidic protein and telomerase expression increased gradually after injury, peaked at 28 days, and then gradually decreased. Spearman rank correlation showed a positive correlation between glial fibrillary acidic protein expression and telomerase expression in the glial scar. These results suggest that telomerase promotes glial scar formation.

Key words: spinal cord injury, glial scar, telomerase, astrocytes, glial fibrillary acidic protein