中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (11): 2448-2449.doi: 10.4103/1673-5374.335787

• 观点:退行性病与再生 • 上一篇    下一篇

阿尔茨海默病建模:对更好的可转化和可复制小鼠模型的考虑

  

  • 出版日期:2022-11-15 发布日期:2022-04-22

Modeling Alzheimer’s disease: considerations for a better translational and replicable mouse model

Joshua D. Cho, Mu Yang, Ismael Santa-Maria*   

  1. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Department of Pathology & Cell Biology, Columbia University, New York, NY, USA (Cho JD, Santa-Maria I)
    The Mouse NeuroBehavior Core. Institute for Genomic Medicine, Columbia University, New York, NY, USA (Yang M)
  • Online:2022-11-15 Published:2022-04-22
  • Contact: Ismael Santa-Maria, is2395@cumc.columbia.edu.

摘要: https://orcid.org/0000-0003-2801-5020 (Ismael Santa-Maria)

Abstract: Alzheimer’s disease (AD) mouse models have proven to be an invaluable tool for deepening our understanding of disease mechanisms and for developing therapeutics. However, one common frustration is the lack of replicability in behavioral findings. As we have discussed in our recent publication (Cho et al., 2021), in the htau mouse model, the cognitive impairment reported in the original study has not been consistently replicated by different labs over the past decade. This variability in behavioral findings seems to exist in many, if not all, AD mouse models that have been behaviorally evaluated.