中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (11): 833-836.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury

  

  • 收稿日期:2011-11-05 修回日期:2012-03-06 出版日期:2012-04-15 发布日期:2012-04-15

Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury

Feng Xiao1, Liangzhi Xiong2, Qingxiu Wang2, Long Zhou1, Qingshan Zhou3   

  1. 1 Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China
    2 Department of Anesthesiology, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China
    3 Department of Anesthesiology, People’s Hospital Affiliated to Wuhan University Medical College, Wuhan 430070, Hubei Province, China
  • Received:2011-11-05 Revised:2012-03-06 Online:2012-04-15 Published:2012-04-15
  • Contact: Qingxiu Wang, Department of Anesthesiology, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China
  • About author:Feng Xiao★, Master, Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China

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Abstract:

A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ischemia/reperfusion significantly decreased infarct volume. Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus, but nuclear factor kappa B expression was unaltered. In addition, the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion. These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.

Key words: ketamine, ischemia/reperfusion, c-Jun, nuclear factor kappa B, infarct volume