中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (12): 2687-2688.doi: 10.4103/1673-5374.335820

• 观点:退行性病与再生 • 上一篇    下一篇

帕金森病中的 Alpha-Klotho:关于实验证据和潜在临床意义的观点

  

  • 出版日期:2022-12-15 发布日期:2022-05-05

Alpha-Klotho in Parkinson’s disease: a perspective on experimental evidence and potential clinical implications

Piergiorgio Grillo, Michele Basilicata, Tommaso Schirinzi*   

  1. Unit of Neurology, Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy (Grillo P, Schirinzi T)
    Department of Experimental Medicine and Surgery, University of Roma Tor Vergata, Rome, Italy (Basilicata M)
  • Online:2022-12-15 Published:2022-05-05
  • Contact: Tommaso Schirinzi, MD, PhD, t.schirinzi@yahoo.com or tommaso.schirinzi@uniroma2.it.

摘要: https://orcid.org/0000-0002-2517-6278 (Tommaso Schirinzi)

Abstract: α-Klotho protein (KL) has been discovered more than 20 years ago, and immediately emerged as a master regulator of aging-related processes, which basically operates as an anti-aging factor. It is expressed through the entire human body, representing the choroid plexus and the kidney as the most active sources at the central nervous system (CNS) and periphery level respectively. To a lesser extent, also the parathyroid gland, the adipose tissue, and the liver express KL.