中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 115-116.doi: 10.4103/1673-5374.340410

• 观点:退行性病与再生 • 上一篇    下一篇

阿尔茨海默病的脑网络调节:临床表型和机会之窗

  

  • 出版日期:2023-01-15 发布日期:2022-06-16

Brain network modulation in Alzheimer’s disease: clinical phenotypes and windows of opportunity

Lorenzo Pini*    

  1. Padova Neuroscience Center, University of Padova, Padova, Italy
  • Online:2023-01-15 Published:2022-06-16
  • Contact: Lorenzo Pini, PhD, lorenzo.pini@unipd.it.

摘要: https://orcid.org/0000-0002-9305-3376 (Lorenzo Pini)

Abstract: Dementia, for which there is no cure or effective treatment, is the leading cause of disability and death worldwide. Due to the high global prevalence and economic impact on families, caregivers, and communities, this condition represents one of the most significant public health challenges of our time. Dementia is an umbrella term describing a range of progressive neurodegenerative diseases, including Alzheimer’s disease (AD), which is the most common cause of cognitive and functional impairment among older adults. The presence of misfolded protein aggregates characterizes neurodegenerative disorders (e.g., amyloid-beta (Aβ) and tau in AD). Stemming from this, advancements in the molecular imaging field paved the way to new experimental AD treatments targeting Aβ. However, the results have been disappointing so far, and there is an ongoing debate about the emerging role and efficacy of anti-Aβ monoclonal antibodies (Musiek and Bennett, 2021), stressing the need for alternative biomarkers to guide new, effective preventive, and therapeutic interventions. Here, we report recent advancements in the field of functional connectivity in AD, underscoring the link with the underlying molecular pathology. We then discuss the meaning of the interplay between AD phenotypes, disease stage, and brain stimulation interventions.