中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 121-122.doi: 10.4103/1673-5374.343893

• 观点:退行性病与再生 • 上一篇    下一篇

髓磷脂缺乏症:阿尔茨海默病的新关键驱动因素

  

  • 出版日期:2023-01-15 发布日期:2022-06-17

Myelin lipid deficiency: a new key driver of Alzheimer’s disease

Shulan Qiu, Juan Pablo Palavicini, Xianlin Han*   

  1. Barshop Institute for Longevity and Aging Studies, Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
  • Online:2023-01-15 Published:2022-06-17
  • Contact: Xianlin Han, PhD, hanx@uthscsa.edu.
  • Supported by:
    This work was supported by National Institute on Aging RF1 AG061872 (to XH); NIH High Priority, Short-Term Project Award R56 AG061729 (to XH); National Institute on Aging RF1 AG061729 (to XH).

摘要: https://orcid.org/0002-8615-2413 (Xianlin Han)

Abstract: Lipids play essential biological functions that include acting as components of biological membranes, energy storage, signaling, nutrients, transporters, enzyme activators, among others. Compared with the multiple research methods to assess DNA, RNA, and protein content, location, and function in cells, there are relatively fewer methods to study lipids. Therefore, lipid-oriented mechanistic studies remain rare and challenging. Lipidomics which allows large-scale analysis of cellular lipids, is a critical strategy for achieving this. One revolutionary advance in lipidomics pioneered by our group is the development of multidimensional mass spectrometry-based shotgun lipidomics, which has become a foundational analytical technology platform among current lipidomics practices due to its high efficiency, sensitivity, and reproducibility, as well as its broad coverage and minimal batch effects.