中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 135-136.doi: 10.4103/1673-5374.343906

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

可见光光学相干断层扫描纤维成像表征小鼠单轴突束水平的视网膜神经节细胞损伤

  

  • 出版日期:2023-01-15 发布日期:2022-06-17

Characterization of retinal ganglion cell damage at single axon bundle level in mice by visible-light optical coherence tomography fibergraphy

Xiaorong Liu*, Hao F. Zhang   

  1. Department of Biology, Department of Psychology, Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA (Liu X)
    Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA (Zhang HF)
  • Online:2023-01-15 Published:2022-06-17
  • Contact: Xiaorong Liu, PhD, xl8n@virginia.edu.
  • Supported by:
    This work was supported by National Institute of Health (NIH) grants R01EY029121 (to XL and HFZ) and U01EY033001 (to HFZ).

摘要: https://orcid.org/0000-0002-7655-6342 (Xiaorong Liu)

Abstract: Retinal ganglion cells (RGCs) receive synaptic inputs through their dendritic trees in the inner plexiform layer (IPL) and convey the visual information via their axons which form the optic nerve to the brain (Sanes and Masland, 2015). In glaucoma, RGCs and their axons degenerate and die, leading to irreversible vision loss and eventually blindness if left untreated (Quigley, 2016). The self-destructive programs in RGCs induced by glaucomatous insults are often spatially compartmentalized (Syc-Mazurek and Libby, 2019), which results in changes in the IPL, the ganglion cell layer, and the retinal nerve fiber layer (RNFL) before cell death in humans and rodents (Wollstein et al., 2012; Chen et al., 2015; Grannonico et al., 2021). Characterizing RGC morphological changes is thus potentially pertinent for timely intervention to preserve RGCs and vision, but much remains unknown to establish a sensitive and specific marker of RGC damage for better diagnosis and management of glaucoma.