中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (11): 867-873.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months

  

  • 收稿日期:2011-11-01 修回日期:2012-02-24 出版日期:2012-04-15 发布日期:2012-04-15

Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months

Xuezhu Song1, Lixin Han2, Yan Liu1   

  1. 1  Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China
    2  Magnetic Resonance Center of Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China
  • Received:2011-11-01 Revised:2012-02-24 Online:2012-04-15 Published:2012-04-15
  • Contact: Yan Liu, M.D., Chief physician, Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China liuyanooo@126.com
  • About author:Xuezhu Song★, Master, Attending physician, Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China (now working in Shunde Guizhou Hospital)

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Abstract:

A total of 29 patients were treated within 48 hours after acute subcortical cerebral infarction with Xuesaitong or Xuesaitong plus human urinary kallidinogenase for 14 days. Neurological deficits, activity of daily living, and evaluations of distal upper limb motor functions at the 6-month follow-up showed that patients treated with Xuesaitong plus human urinary kallidinogenase recovered better than with Xuesaitong alone. In addition, functional MRI revealed that activation sites were primarily at the ipsilesional side of injury in all patients. Human urinary kallidinogenase induced hyperactivation of the ipsilesional primary sensorimotor cortex, premotor cortex, supplementary motor area, and contralesional posterior parietal cortex. Results showed that human urinary kallidinogenase improved symptoms of neurological deficiency by enhancing remodeling of long-term cortical motor function in patients with acute cerebral infarction.

Key words: cerebral infarction, functional magnetic resonance imaging, human urinary kallidinogenase, motor function remodeling, neural regeneration