中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 258-266.doi: 10.4103/1673-5374.346460

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

胞浆型磷脂酶A2在中枢神经系统创伤中的功能和机制

  

  • 出版日期:2023-02-15 发布日期:2022-08-05

Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma

Hao-Jie Zhang1, 2, 3, #, Yi-Tuo Chen1, 2, 3, #, Xin-Li Hu1, 2, 3, Wan-Ta Cai1, 2, 3, Xiang-Yang Wang1, 2, 3, Wen-Fei Ni1, 2, 3, *, Kai-Liang Zhou1, 2, 3, *   

  1. 1Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; 2Zhejiang Provincial Key Laboratory of Orthopedics, Wenzhou, Zhejiang Province, China; 3The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
  • Online:2023-02-15 Published:2022-08-05
  • Contact: Wen-Fei Ni, MD, PhD, niwenfei@126.com; Kai-Liang Zhou, MD, PhD, zhoukailiang@wmu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 82072192 (to KLZ); Public Welfare Technology Research Project of Zhejiang Province, No. LGF20H150003 (to KLZ); the Natural Science Foundation of Zhejiang Province, Nos. LY17H060009 and Y21H060050 (both to WFN); and Wenzhou Science and Technology Bureau Foundation, No. Y20210438 (to KLZ).

摘要: https://orcid.org/0000-0002-5344-1497 (Wen-Fei Ni); https://orcid.org/0000-0001-7795-576X (Kai-Liang Zhou)

Abstract: Central nervous system (CNS) trauma, including traumatic brain injury and spinal cord injury, has a high rate of disability and mortality, and effective treatment is currently lacking. Previous studies have revealed that neural inflammation plays a vital role in CNS trauma. As the initial enzyme in neuroinflammation, cytosolic phospholipase A2 (cPLA2) can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release lysophospholipids and ω3-polyunsaturated fatty acid dominated by arachidonic acid, thereby inducing secondary injuries. Although there is substantial fresh knowledge pertaining to cPLA2, in-depth comprehension of how cPLA2 participates in CNS trauma and the potential methods to ameliorate the clinical results after CNS trauma are still insufficient. The present review summarizes the latest understanding of how cPLA2 participates in CNS trauma, highlighting novel findings pertaining to how cPLA2 activation initiates the potential mechanisms specifically, neuroinflammation, lysosome membrane functions, and autophagy activity, that damage the CNS after trauma. Moreover, we focused on testing a variety of drugs capable of inhibiting cPLA2 or the upstream pathway, and we explored how those agents might be utilized as treatments to improve the results following CNS trauma. This review aimed to effectively understand the mechanism of cPLA2 activation and its role in the pathophysiological processes of CNS trauma and provide clarification and a new referential framework for future research.

Key words: autophagy, cytosolic phospholipase A2, drugs, lysosome membrane permeability, mitogen-activated protein kinase, neuroinflammation, spinal cord injury, traumatic brain injury