中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 317-318.doi: 10.4103/1673-5374.343907

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

线粒体在损伤后神经元恢复中的作用

  

  • 出版日期:2023-02-15 发布日期:2022-08-06

The role of mitochondria in the recovery of neurons after injury

Taylor McElroy#, Rola S. Zeidan#, Laxmi Rathor, Sung Min Han*, Rui Xiao*   

  1. Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, FL, USA
  • Online:2023-02-15 Published:2022-08-06
  • Contact: Sung Min Han, PhD, han.s@ufl.edu; Rui Xiao, PhD, rxiao@ufl.edu.
  • Supported by:
    This work was supported by grants from the National Institute on Aging (AG063766 and AG028740 to RX, AG066654 to SMH, T32AG062728 to TM), the American Cancer Society (RSG-17-171-01-DMC to RX), and the American Federation for Aging Research (AGR DT 07-2502019 and AGR DTD 09-15-2021 to SMH). 

摘要: https://orcid.org/0000-0001-5541-6685 (Rui Xiao)

Abstract: Mitochondria are well characterized by their fundamental functions in regulating cellular homeostasis, including energy and iron metabolism. These functions are essential in neurons with high metabolic demands and elongated neuronal processes. Mitochondria dynamically change morphology, localization, and activity to match neurons’ spatial and temporal demands. Mitochondrial dysfunctions have been associated with many neurological disorders. Recent studies highlight that mitochondria also act as central regulators of the neuronal response to injury. Here, we discuss important findings that support the critical regulation of mitochondrial dynamics, energy metabolism, and iron homeostasis in the repair of damaged neurons.