中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (3): 176-181.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Neuroprotective effects of total saponins from Rubus parvifolius L. on cerebral ischemia/ reperfusion injury in rats

  

  • 收稿日期:2011-07-09 修回日期:2011-11-01 出版日期:2012-01-25 发布日期:2012-01-25

Neuroprotective effects of total saponins from Rubus parvifolius L. on cerebral ischemia/ reperfusion injury in rats

Jisheng Wang1, Fang Zhang1, Li Tang1, Liqiong Sun1, Xiaolin Song1, Lisha Cao1, Zongyin Qiu2, Chenglin Zhou2   

  1. 1 The Third Hospital of Mianyang, Mianyang 621000, Sichuan Province, China
    2 Department of Pharmacy, Chongqing University of Medical Science, Chongqing 400016, China
  • Received:2011-07-09 Revised:2011-11-01 Online:2012-01-25 Published:2012-01-25
  • Contact: Ji-sheng Wang, the Third Hospital of Mianyang, Mia-nyang 621000, Sichuan Province, China 24475434@qq.com
  • About author:Jisheng Wang☆, Doctor, Associate chief pharmacist, the Third Hospital of Mia-nyang, Mianyang 621000, Sichuan Province, China

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Abstract:

This study examines the neuroprotective effects and mechanisms of action of total saponins from Rubus parvifolius L. (TSRP) on focal cerebral ischemia and reperfusion injury in rats. Focal cerebral ischemia and reperfusion injury was performed in rats using the suture method. The results indicate that intragastric injection of TSRP, at 5, 10 and 20 mg/kg, could decrease neurological impairment, reduce cerebral infarct volume, diminish pathological changes, and significantly inhibit the apoptosis of neurons surrounding the ischemic area. In addition, TSRP upregulated the expression of the anti-apoptotic factor Bcl-2, at the protein and mRNA levels, and it downregulated the expression of the pro-apoptotic factor Bax, at the protein and mRNA levels. These findings indicate that TSRP protects against cerebral ischemia/reperfusion injury, and that it may do so by regulating the expression of Bcl-2 and Bax.

Key words: total saponins of Rubus parvifolius L., cerebral ischemia/reperfusion, apoptosis, Bcl-2, Bax