中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (3): 187-190.

• 原著:退行性病与再生 • 上一篇    下一篇

Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression

  

  • 收稿日期:2011-09-06 修回日期:2011-12-06 出版日期:2012-01-25 发布日期:2012-01-25

Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression

Wentao Fan, Qian Wang, Yongmei Yan   

  1. Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China
  • Received:2011-09-06 Revised:2011-12-06 Online:2012-01-25 Published:2012-01-25
  • Contact: Wen-tao Fan, Shaanxi University of Chinese Medicine, Xia-nyang 712000, Shaanxi Province, China fwtqq@tom.com
  • About author:Wentao Fan★, Master, Attending physician, Lectur-er, Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China

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Abstract:

The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac.

Key words: Xingnao Jieyu capsule, poststroke depression, hippocampus, neuron, traditional Chinese medicine, neural regeneration