中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (3): 212-218.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain

  

  • 收稿日期:2011-09-09 修回日期:2011-12-25 出版日期:2012-01-25 发布日期:2012-01-25

Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain

Junying Wang, Junling Liu, Shuping Chen, Yonghui Gao, Fanying Meng, Lina Qiao   

  1. Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2011-09-09 Revised:2011-12-25 Online:2012-01-25 Published:2012-01-25
  • Contact: Junl-ing Liu, Professor, Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China Jlliu2765@yahoo.com.cn
  • About author:Junying Wang☆, M.D., Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

PDF

1001

Abstract:

The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. The effects of electroacupuncture increased with prolonged time, but the above-mentioned effects decreased in memory-deficient animals. Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory.

Key words: acetylcholinesterase, chronic pain, cumulative effect, electroacupuncture analgesia, hippocampus, M1R mRNA expression, vesicular acetylcholine transporter