中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (2): 125-130.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia

  

  • 收稿日期:2011-10-06 修回日期:2011-12-19 出版日期:2012-01-15 发布日期:2012-01-15

Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia

Qinhua Guo1, Jin Lan1, Weiqiao Zhang1, Pin Guo1, Liemei Guo1, Zhiqiang Li2, Yongming Qiu1   

  1. 1 Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    2 Central Hospital of Fengxian District, Shanghai Neurological Research Institute of Anhui University of Science & Technology,Shanghai 201400, China
  • Received:2011-10-06 Revised:2011-12-19 Online:2012-01-15 Published:2012-01-15
  • Contact: Yongming Qiu, Doctor, Professor, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; Zhiqiang Li, Doctor, Central Hospital of Fengxian District, Shanghai Neurological Research Institute of Anhui University of Science & Technology, Shanghai 201400, China Qiuzhoub@hotmail.com; lzq_999@163.com
  • About author:Qinhua Guo☆, Studying for doctorate, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

PDF

1059

Abstract:

The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and hippocampus. After 24 hours of ischemia, expression of glutamate transporter-1 significantly decreased in the cerebral cortex and hippocampus, which was accompanied by neuronal necrosis. At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis. Expression of glutamate-aspartate transporter remained unchanged at 6 hours-7 days after ischemia. These results suggested that glutamate transporter levels were altered at different periods of cerebral ischemia.

Key words: apoptosis, excitatory amino acid carrier 1, global cerebral ischemia, glutamate- aspartate transporter, glutamate transporter, glutamate transporter-1, neuroprotection