Contact:
Zheng, Chief physician,Doctoral supervisor,Department of Cardiovascular Disease, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China Zhengyang1288@126.com
About author:Quan Liu☆, Ph.D.,Professor, Department of Cardiovascular Disease, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
(1) The distribution of cardiac sympathetic and parasympathetic nerves was examined. Sympathetic nerves function on cardiac adrenergic receptors through the release of norepinephrine and catecholamine. The adrenergic receptors include α and β isoforms, and the regulatory functions of sympathetic nerves are mainly regulated by a β-adrenergic effect.
(2) The main markers of cardiac autonomic nerves are tyrosine hydroxylase and acetylcholine transferase. Immunohistochemical staining revealed that cardiac autonomic nerves are unevenly distributed in different sites, and are mainly located at the surface of the atrium and pulmonary vein, forming a ganglia plexus.
(3) Cardiac autonomic nerves play an important role in the occurrence, maintenance and symptoms of arrhythmia.
(1)文章描述了心脏交感神经和副交感神经的分布。交感神经通过释放去甲肾上腺素和儿茶酚胺类作用于心肾上腺素能受体,肾上腺素能受体分为α和β亚型,交感神经的调节功能主要表现为β肾上腺素能效应。副交感神经对心脏功能的调节是通过释放乙酰胆碱作用于毒蕈碱样胆碱能M受体。
(2)心脏自主神经的主要标记物为酪氨酸羟化酶和乙酰胆碱转移酶。通过免疫组织化学方法标记观察心脏自主神经在各部位分布不均匀,主要聚集在心房和肺静脉表面构成神经节丛。
(3)心脏自主神经对心律失常的发生、维持以及症状的产生都具有重要作用。