中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (1): 6-7.

• 观点:脊髓损伤修复保护与再生 •    下一篇

使用数据标准及其本体促进脊髓损伤研究的透明度

  

  • 出版日期:2014-01-05 发布日期:2014-01-05

Facilitating transparency in spinal cord injury studies using data standards and ontologies

Vance P. Lemmon1, 2, 3, Saminda Abeyruwan3, 4, Ubbo Visser3, 4 , John L. Bixby1, 2, 3, 5   

  1. 1 Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA; 2 Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA; 3 Center for Computational Science, University of Miami, Miami, FL 33146, USA; 4 Department of Computer Science, University of Miami, Miami, FL 33146, USA; 5 Department of Molecular & Cellular Pharmacology, University of Miami, Miami, FL 33136, USA
  • Online:2014-01-05 Published:2014-01-05

摘要:

目前,针对脊髓损伤(SCI),创伤性脑损伤(TBI)和外周神经损伤治疗方法的研发上,进展一直很缓慢。在过去30年里,我们从调节轴突生长的内在因素和环境因素这两个方面得到了很大启发,但这一庞大的信息量尚未给临床研究提供可用的治疗方案。会有许多原因导致治疗瓶颈,但目前科学界正在逐渐形成一个共识,即缺乏一种对实验设计和报告的统一标准。由于申报标准的缺失,甚至已被普遍接受的关键词定义也会给数据挖掘和有关神经可塑性与再生的生物信息学分析造成困难。这篇简短的审查将考虑相关背景并尝试在轴突再生领域内找到这一问题的潜在解决方案。

Abstract:

Progress in developing robust therapies for spinal cord injury (SCI), traumatic brain injury (TBI) and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both the intrinsic factors and the environmental factors that regulate axon growth, but this large body of information has not yet resulted in clinically available therapeutics. Prof. Lemmon and his team from University of Miami in USA proposed this therapeutic bottleneck has many root causes, but a consensus is emerging that one contributing factor is a lack of standards for experimental design and reporting. The absence of reporting standards, and even of commonly accepted definitions of key words, also make data mining and bioinformatics analysis of neural plasticity and regeneration difficult, if not impossible. These findings, published in the Neural Regeneration Research (Vol. 9, No. 1, 2014), this short review will consider relevant background and potential solutions to this problem in the axon regeneration domain.