中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (4): 356-361.

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

轴突生长的信号灯:蛋白多糖和神经元受体

  

  • 收稿日期:2014-01-08 出版日期:2014-02-25 发布日期:2014-02-25

Traffic lights for axon growth: proteoglycans and their neuronal receptors

Shen Y   

  • Received:2014-01-08 Online:2014-02-25 Published:2014-02-25

Abstract:

Axon growth is a central event in the development and post-injury plasticity of the nervous system. Growing axons encounter a wide variety of environmental instructions. Much like traffic lights in controlling the migrating axons, chondroitin sulfate proteoglycans (CSPGs) and heparan sulfate proteoglycans (HSPGs) often lead to “stop” and “go” growth responses in the axons, respectively. Recently, the LAR family and NgR family molecules were identified as neuronal receptors for CSPGs and HSPGs. These discoveries provided molecular tools for further study of mechanisms underlying axon growth regulation. More importantly, the identification of these proteoglycan receptors offered potential therapeutic targets for promoting post-injury axon regeneration.

Key words: axonal regeneration, chondroitin sulfate and heparan sulfate proteoglycans