中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (9): 968-972.doi: 10.4103/1673-5374.133148

• 原著:退行性病与再生 • 上一篇    下一篇

针灸可明显减轻阿尔茨海默病大鼠神经元的水肿

  

  • 收稿日期:2014-03-12 出版日期:2014-05-20 发布日期:2014-05-20
  • 基金资助:

    国家自然科学基金(30772837);武汉市晨光科技计划(200850731347)

Acupuncture and moxibustion reduces neuronal edema in Alzheimer’s disease rats

Hua Zhou, Guojie Sun, Lihong Kong, Yanjun Du, Feng Shen, Shuju Wang, Bangguo Chen, Xiaoling Zeng   

  1. Hubei University of Chinese Medicine, Wuhan, Hubei Province, China
  • Received:2014-03-12 Online:2014-05-20 Published:2014-05-20
  • Contact: Guojie Sun, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China, sunguojie@sina.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 30772837; the Wuhan Municipal “Morning Sun” Science and Technology Plan, No. 200850731347.

摘要:

为验证Wnt信号系统失常可能与其阿尔茨海默的病理变化有关,轴蛋白和β连环蛋白与wnt信号系统联系密切的理论,实验建立了阿尔茨海默病大鼠模型,并以百会(GV20)、肾俞(BL23)穴进行艾灸、电针、电针+艾灸预处理,发现大鼠海马组织轴蛋白的表达下降,β-连环蛋白的表达上调,神经元细胞质水肿程度明显减轻。说明针灸减轻阿尔茨海默病神经元损伤的机制可能与Wnt信号转导通路轴蛋白和β连环蛋白的表达改变有关。

Abstract:

To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer’s disease, we established a rat model of Alzheimer’s disease and measured axin and β-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacupuncture, or both, at Baihui (GV20) and Shenshu (BL23). Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuroprotective effect of acupuncture and moxibustion in Alzheimer’s disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway.

Key words: nerve regeneration, brain injury, acupuncture and moxibustion, pretreatment, Alzheimer’s disease, axin, β-catenin, NSFC grant, neural regeneration