视神经损伤
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Figure 1｜Processing of fundus images.
Standardized digital fundus photographs were taken within 72 hours of hospital admission by dilating the patient’s pupil with 1% tropicamide eye drops (Xingqi Eye Medicine, Inc., Shenyang, China). To ensure consistency, all images were captured using the same camera model (Topcon TRC-50DX, Topcon, Inc., Tokyo, Japan) and centered on the optic disc, with a 50° range. Both the left and the right eyes were photographed, and the parameters were averaged and analyzed for each patient. The retinal vascular parameters were graded at the Guangdong-Hongkong-Macau Institute of Central Nervous System (CNS) Regeneration (GHMICR) of Jinan University using Canvus 14 (Advanced Cell Diagnostics, Inc., Newark, CA, USA) and NeuroLucida (MBF Biosciences Inc., Boston, MA, USA) software. This quantitative method was based on our previous study (Zhao et al., 2020; Figure 1), which also provides detailed information on the definition and automatic calculation of these parameters.