Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy

doi:10.3969/j.issn.1673-5374.2012.35.002

Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (35): 2755-2760.doi: 10.3969/j.issn.1673-5374.2012.35.002

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Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy

Wanlong Xu^{1, 2}, Xilinbaoleri¹, Hao Liu¹, Ruozheng Wang¹, Jingping Bai¹

1 The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China 2 People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, Xinjiang Uygur Autonomous Region, China

Received:2012-07-25 Revised:2012-10-10 Online:2012-12-15 Published:2012-10-10
Contact: Jingping Bai, Professor, Doctoral supervisor, the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China，xjbonetumor@126.com
About author:Wanlong Xu☆, M.D., the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China; People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Supported by:
This study was supported by the National Natural Science Foundation of China, No. 81060182; the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2012211B34; the Key Technology Research and Development and Major Program of Xinjiang Uygur Autonomous Region, No. 200833116.

Abstract

Abstract:

Tumor models were simulated in purebred Beagles at the T9-10 levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T9-10 levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy.

Key words: Image-guided radiation therapy, conventional radiation therapy, spinal cord, neurons, apoptosis, Fas, heat shock protein 70, biological safety, vertebral body, tumor

Wanlong Xu, Xilinbaoleri, Hao Liu, Ruozheng Wang, Jingping Bai. Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy[J]. Neural Regeneration Research, 2012, 7(35): 2755-2760.

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Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy

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