Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging studyChanges in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study

doi:10.3969/j.issn.1673-5374.2013.05.012

Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (5): 469-473.doi: 10.3969/j.issn.1673-5374.2013.05.012

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Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging studyChanges in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study

Ah Young Lee¹, Sung Ho Jang¹, Sang Seok Yeo¹, Ensil Lee², Yun Woo Cho¹, Su Min Son¹

1 Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namku, Daegu 705-717, Republic of Korea
2 Department of Pediatrics, College of Medicine, Yeungnam University, Namku, Daegu 705-717, Republic of Korea

Received:2012-06-16 Revised:2012-11-07 Online:2013-02-15 Published:2013-02-15
Contact: Su Min Son, M.D., Associate professor, Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University 317-1, Daemyungdong, Namku, Daegu 705-717, Republic of Korea, sumin430@hanmail.net.
About author:Ah Young Lee☆, M.D.
Supported by:
This research was supported by the Basic Scientific Research Program of National Research Foundation of Korea Funded by Ministry of Education, Science and Technology, No. 2011-0003426.

Abstract

Abstract:

We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients’ functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg’s balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected.

Key words: neural regeneration, neuroimaging, Dandy-Walker malformation, cerebellar peduncle, ataxia, cerebral palsy, functional ambulation category, Berg’s balance scale, fractional anisotropy, apparent diffusion coefficient, diffusion tensor tractography, diffusion tensor imaging, grants-supported paper, photographs-containing paper, neuroregeneration

Ah Young Lee, Sung Ho Jang, Sang Seok Yeo, Ensil Lee, Yun Woo Cho, Su Min Son. Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging studyChanges in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study[J]. Neural Regeneration Research, 2013, 8(5): 469-473.

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Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging studyChanges in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study

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