Mechanism of Erhuang capsule for treatment of multiple sclerosis

doi:10.3969/j.issn.1673-5374.2013.06.005

Abstract

Abstract:

Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.

Key words: neural regeneration, traditional Chinese medicine, neurodegenerative diseases, oligodendrocyte precursor cells, Erhuang capsule, Chinese compound recipe, methods of tonifying the kidney, resolving phlegm and activating blood, oligodendrocyte lineage gene 2, experimental autoimmune encephalomyelitis, multiple sclerosis, central nervous system, grants-supported paper, photographs-containing paper, neuroregeneration

Kangning Li, Yongping Fan, Tao Yang, Lei Wang. Mechanism of Erhuang capsule for treatment of multiple sclerosis[J]. Neural Regeneration Research, 2013, 8(6): 523-531.

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