Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (27): 2520-2530.doi: 10.3969/j.issn.1673-5374.2013.27.003

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Propofol’s effect on the sciatic nerve Harmful or protective?

Yi Sun, Xizhe Zhang, Qi Zhou, Yong’an Wang, Yiwen Jiang, Jian Cao   

  1. Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China
  • Received:2013-06-05 Revised:2013-08-03 Online:2013-09-25 Published:2013-09-25
  • Contact: Jian Cao, M.D., Associate chief physician, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China, caojian2005088@ hotmail.com.
  • About author:Yi Sun, Professor, Chief physician, Master’s supervisor. Yi Sun and Xizhe Zhang contributed equally to this work.
  • Supported by:

    This study was financially supported by the Science and Technology Bureau of Inner Mongolia Autonomous Region, No. Y2011024007.

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Abstract:

Propofol can inhibit the inflammatory response and reduce the secretion and harmful effects of as-trocyte-derived proinflammatory cytokines. In this study, after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L4–6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were alleviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration following sciatic nerve injury.

Key words: neural regeneration, peripheral nerve injury, propofol, nuclear factor kappa B, sciatic nerve injury, inflammatory response, nerve conduction, immunosuppression, myelin sheath, grant-supported paper, neuroregeneration