Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (28): 2641-2648.doi: 10.3969/j.issn.1673-5374.2013.28.006

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Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction

Yanan Zhang1, Sha Yang2, 3, 4, Xiaonong Fan2, 3, 4, 5, Shu Wang2, 3, 4, Nina He6, Lingxin Li7, Ding Luo8, Xuemin Shi1   

  1. 1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    2 Acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    3 Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300193, China
    4 Tianjin Key Laboratory of Acupuncture & Moxibustion Science, Tianjin 300193, China
    5 Three-level Laboratory of Acupuncture Dose-Effect Relationship, State Administration of Traditional Chinese Medicine, Tianjin 300193, China
    6 Wuhai Hospital of Traditional Chinese Medicine, Wuhai 016000, Inner Mongolia Autonomous Region, China
    7 Department of Rehabilitation Medicine, West China Medical School, West China Hospital Sichuan University, Chengdu 610041, Sichuan Province, China
    8 Postgraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2013-02-02 Revised:2013-09-02 Online:2013-10-05 Published:2013-10-05
  • Contact: Shu Wang, M.D., Professor, Chief physician, Acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Key Laboratory of Acupuncture & Moxibustion Science, Tianjin 300193, China, wangs2008@163.com.
  • About author:Yanan Zhang, M.D.
  • Supported by:

    This project was funded by Development Plan (973 Plan) of National Critical and Basic Research, No. 2012CB518505, 2010CB 530500, 2006CB504504.

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Abstract:

The individual difference and non-repeatability in acupuncture have not only restricted the devel-opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan (PC6) with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 se-conds significantly increased cerebral blood flow and decreased the ratio of infarct volume. Interac-tions between frequency and duration play a critical role in quantified acupuncture therapy.

Key words: neural regeneration, acupoint, quantified acupuncture, Neiguan, middle artery occlusion injury, lift-ing and thrusting method, orthogonal design, lifting and thrusting frequency, acupuncture duration, grants-supported paper, neuroregeneration