Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (4): 407-412.doi: 10.4103/1673-5374.128246

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Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson’s disease

Long Teng, Fang Hong, Chenguang Zhang, Jiancheng He, Haiying Wang,   

  1. Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • Received:2014-01-18 Online:2014-02-25 Published:2014-02-25
  • Contact: Jiancheng He, M.D., Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, hejc8163@163.com. Haiying Wang, M.D., Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, wanghaiying _7@hotmail.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 30672684, 30973722; Science and Technology Support Traditional Chinese Drug Research and Development Project of Shanghai, No. F50102; Traditional Chinese Medicine Research Fund of Shanghai Municipal Health Bureau, No. 2012J009A; Annual Research Budget of Shanghai University of Traditional Chinese Medicine in 2013, No. 2013JW25.

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Abstract:

Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson’s disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson’s disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson’s disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson’s disease by modulating neurotransmitter signaling in the corpus striatum.

Key words: nerve regeneration, traditional Chinese medicine, Parkinson’s disease, dyskinesia, excitatory amino acid, inhibitory amino acid, neurobehavior, Compound Formula Rehmannia, NSFC grant, neural regeneration