Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (6): 616-621.doi: 10.4103/1673-5374.130105

Previous Articles     Next Articles

Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease

Nour Erekat 1, Ahed Al-Khatib 2, Muhammed Al-Jarrah 3   

  1. 1 Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan
    2 Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    3 Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan (Current address: Fatima College of Health Sciences (FCHS). Abu Dhabi, UAE)
  • Received:2014-01-01 Online:2014-03-22 Published:2014-03-22
  • Contact: Muhammed Al-Jarrah, Ph.D., P.T., Department of Rehabilitation Sciences, Faculty of Applied Medical sciences, Jordan University of Science and Technology, 22110 P.O. box 3030. Irbid, Jordan, jarrahm@just.edu.jo.
  • Supported by:

    This study was financially supported by the Deanship of Research at Jordan University of Science and Technology, Irbid, Jordan.

PDF

694

Abstract:

Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopaminergic neuronal death. This study was designed to further investigate what effects are produced by heat shock protein 90 after endurance exercise training. Immunohistochemistry results showed that exercise training significantly inhibited heat shock protein 90 overexpression in the soleus and gastrocnemius in Parkinson’s disease rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease.

Key words: nerve regeneration, heat shock protein 90, Parkinson’s disease, exerecise, soleus muscle, gastrocnemius muscle, skeletal muscle, treadmill excise, neural regeneration