Abstract:

Ubiquitin homeostasis: From neural stem cell differentiation to neuronal development Ubiquitin (Ub) is a well-known eukaryotic protein that exerts diverse signaling functions inside the cells, including targeting its substrates for proteasomal degradation. Based on Prof. Kwon-Yul Ryu et al.' (University of Seoul, Republic of Korea) recent reports, they speculate that measuring cellular levels of free Ub will be essential for the optimal differentiation of neural stem cells into neurons and for neuronal development. Ub may be one of the key proteins in determining the fate of neural stem cells. Thus, Ub homeostasis should be considered to maximize the efficacy of neural stem cell transplantation. Therefore, their research represents a milestone in the development of a novel and universal therapeutic strategy to overcome various neurodegenerative diseases.