Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (8): 1343-1344.doi: 10.4103/1673-5374.162950

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Neuroprotective effects of monosialotetrahexosylganglioside

Ai-ping Xi, Zhong-xin Xu, Feng-li Liu, Yan-li Xu   

  1. The Affiliated Hospital of Hebei University of Engineering, Handan, Hebei Province, China (Xi AP)
    School of Medicine, Hebei University of Engineering, Handan, Hebei Province, China (Xu ZX, Liu FL, Xu YL)
  • Received:2015-07-23 Online:2015-08-24 Published:2015-08-24
  • Contact: Yan-li Xu, Ph.D., xuyanli@vip.sina.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (General Program), No. 81373095.

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Abstract:

Monosialotetrahexosylganglioside (GM1) is a type of glycosphingolipid containing sialic acid and closely related to cell-cell recognition, adhesion and signal conduction. GM1 is mainly composed of ceramide and oligosaccharide chains, and it is the only ganglioside that can permeate the blood-brain barrier. The present review analyzed the neuroprotective effects of GM1. With further, in-depth study, the molecular mechanisms underlying the neuroprotective effects of ganglioside can be clarified and provide a solid foundation for clinical research. Moreover, well-designed, randomized controlled trials will open up new prospects for the clinical use of ganglioside.