Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (11): 1743-1745.doi: 10.4103/1673-5374.170298

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Novel approaches for the development of peripheral nerve regenerative therapies

Felix Beyer, Patrick Küry *   

  1. Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany
  • Received:2015-10-12 Online:2015-12-07 Published:2015-12-07
  • Supported by:

    Our research on Schwann cell differentiation was supported by grants from the DFG (German Research Council), Novartis Pharma GmbH (Nürnberg, Germany), and Baxter Innovations GmbH (Vienna, Germany)

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Abstract:

The search for active ingredients in polyvalent immunoglobulin preparations (Fc receptor or Schwann cell antigen–directed) as well as studies of S1P receptor activation by means of more specific ligands might further pave the way for novel repair therapies for patients with different peripheral nerve conditions. The studies presented here also demonstrate that Schwann cells exert a high degree of immunocompetence and that multiple signaling interfaces between immune and Schwann cells exist, and these could be explored for pharmacological modulation.