Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (11): 1825-1829.doi: 10.4103/1673-5374.170312

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Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?

Murat Sahin1, *, Huriye Gullu2, Kemal Peker3, Ilyas Sayar4, Orhan Binici2, Huseyin Yildiz5   

  1. 1 Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Amasya, Amasya, Turkey
    2 Department of Anesthesiology and Reanimation, Mengucek Gazi Research and Training Hospital, Erzincan, Turkey
    3 Department of General Surgery, Faculty of Medicine, University of Erzincan, Erzincan, Turkey
    4 Department of Pathology, Faculty of Medicine, University of Erzincan, Erzincan, Turkey
    5 Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Sutcu Imam, Kahramanmaras,Turkey
  • Received:2015-09-08 Online:2015-12-07 Published:2015-12-07
  • Contact: Murat Sahin, M.D.,muratsahin4006@hotmail.com.

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Abstract:

The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 μg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia.

Key words: nerve regeneration, propofol, pre-treatment, spinal cord, ischemia, neuroprotection, paraplegia, neural regeneration