Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (2): 220-221.doi: 10.4103/1673-5374.177717

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Effects of chemical and physical cues in enhancing neuritogenesis and peripheral nerve regeneration

Casey D. Sigerson, Christopher J. Dipollina, Michele Fornaro   

  1. Department of Anatomy, Midwestern University - Chicago College of Osteopathic Medicine, Downers Grove, IL, USA (Sigerson CD, Fornaro M)
    Department of Biomedical Sciences, Midwestern University, College of Health Sciences, Downers Grove, IL, USA (Dipollina CJ)
  • Received:2016-01-28 Online:2016-02-15 Published:2016-02-15
  • Contact: Michele Fornaro, Ph.D.,mforna@midwestern.edu.

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Abstract:

Developing a model that incorporates several of the relevant factors would be of great interest to the field of neuroregeneration. The creation of microenvironments that simultaneously address topography, bound ECM cues and free neurotrophic factors would allow researchers to test for possible additive or synergistic effects due to the combination of factors. Only myriad combinations of biophysical and biochemical cues will allow neuroscientists to elucidate the optimal environment for neuroregeneration. Discoveries in the area of in vitro regeneration will lead to the most important goal for this field of research: the modification of the neural microenvironment in vivo to promote axonal growth and restore neural function.