Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (1): 24-33.doi: 10.4103/1673-5374.243699

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Peripheral nerve regeneration and intraneural revascularization

Martial Caillaud 1 , Laurence Richard 2 , Jean-Michel Vallat 2 , Alexis Desmoulière 1 , Fabrice Billet 1   

  1. 1 University of Limoges, Myelin Maintenance and Peripheral Neuropathies, Faculties of Medicine and Pharmacy, Limoges, France
    2 University Hospital of Limoges, Department of Neurology, “Reference Center for Rare Peripheral Neuropathies”, Department of Neurology, Limoges, France
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Fabrice Billet, PhD, fabrice.billet@unilim.fr
  • Supported by:

    This work was supported by a doctoral fellowship from the ‘Conseil Régional du Limousin’ to MC.

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Abstract:

Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. The current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully.

Key words: compression, crush, transection, Sunderland’s classification, Wallerian degeneration, angiogenesis, traumatic, glycerol