Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (6): 984-990.doi: 10.4103/1673-5374.250577

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Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury

Hui-Jie Wei 1 , Li Liu 1 , Fang-Lian Chen 1 , Dong Wang 1 , Liang Wang 1, 2 , Zeng-Guang Wang 1 , Rong-Cai Jiang 1 , Jing-Fei Dong 1, 3 , Jie-Li Chen 1, 4 , Jian-Ning Zhang 1   

  1. 1 Department of Neurosurgery, Tianjin Medical University General Hospital; Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China
    2 Department of Neurosurgery, Peking University International Hospital, Beijing, China
    3 Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    4 Department of Neurology, Henry Ford Health System, Detroit, MI, USA
  • Online:2019-06-15 Published:2019-06-15
  • Contact: Jian-Ning Zhang, MD, PhD, jianningzhang@hotmail.com; Jie-Li Chen, MD, jieli@neuro.hfh.edu.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 30772229 (to JNZ), No. 81200907 (to HJW); the Natural Science Foundation of Tianjin of China, No. 12JCQNJC06800 (to HJW); the Science and Technology Projects in Key Areas of Traditional Chinese Medicine of Tianjin of China, No. 2018001 (to ZGW); and the Scientific Research Program Project of Tianjin Education Commission of China, No. 2018ZD03 (to ZGW).

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Abstract:

Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function. However, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial pro¬genitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury, and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progen¬itor cells was negatively correlated with blood sugar levels (r =−0.147, P < 0.05). Our results verify that hyperglycemia in patients with traumatic brain injury is associated with decreased numbers of circulating endothelial progenitor cells. This study was approved by Ethical Committee of Tianjin Medical University General Hospital, China (approval No. 200501) on January, 2015. All subjects or guardians pro¬vided informed written consent before enrollment.

Key words: nerve regeneration, endothelial progenitor cells, vascular repair, vascular remodeling, angiogenesis, neovascularization, blood glucose, hyperglycemia, traumatic brain injury, mobilization, suppression, senescence, alternative therapy, brain damage, neural regeneration