Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (12): 2415-2416.doi: 10.4103/1673-5374.313032

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Rogue gene networks gone awry in Alzheimer’s disease

Emily Miyoshi, Vivek Swarup*   

  1. Department of Neurobiology and Behavior, University of California, Irvine, CA, USA (Miyoshi E, Swarup V);Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, CA, USA (Miyoshi E, Swarup V)
  • Online:2021-12-15 Published:2021-05-14
  • Contact: Vivek Swarup, PhD, vivek.swarup@uci.edu.

Abstract: The human brain consists of billions of cells encompassing hundreds of distinct cell-types, each with unique functions and properties. Identification of the molecular architecture of the brain has been revolutionized by next-generation sequencing (NGS), as evident by recent transcriptomic and genetic/epigenetic studies. NGS paved the way to perform large-scale, genome-wide sequencing studies on human postmortem brain tissue, and this offered an unprecedented opportunity to elucidate the genetic bases of polygenic neurological disorders, like Alzheimer’s disease (AD).