Abstract: The hippocampus is involved in important brain functions such as learning and memory, spatial navigation, fear processing, and social behavior (Dudek et al, 2016). The most prominent areas of the hippocampus are typically denoted as the dentate gyrus and the three areas of the cornu ammonis (CA1, CA2, and CA3). Discovered by Lorente de Nó (1934), the CA2 region of the hippocampus is a relatively small area interposed between CA3 and CA1 that forms the nexus linking the input of the entorhinal cortex to the output of CA1 (Chevaleyre and Siegelbaum, 2010). Although little is known about the function of CA2 in detail (Hitti and Siegelbaum, 2014; Dudek et al., 2016), there is currently increasing interest in its physiology and cumulative evidence indicates that this region has important and unique properties as it participates in engram formation, neurodegeneration and information processing (Hainmueller and Bartos, 2018; Pang et al., 2019; Middleton and Mchugh, 2020; Lehr et al., 2021). Recent discoveries have revealed that CA2 is involved in the formation of social and spatio/temporal memories (Hitti and Siegelbaum, 2014; Dudek et al., 2016). In addition, the CA2 network seems to play a critical role in balancing levels of excitation and inhibition in the hippocampus (Boehringer et al., 2017). Importantly, excitation/inhibition imbalances have been implicated in the diverse brain and neurodevelopmental disorders.