Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (2): 451-455.doi: 10.4103/1673-5374.346462

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Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells

Jia-Lin Zhan1, Yan-Ling Huang1, Qiao-Wen Liang1, Xiao-Sheng Qu2, Zi-Mei Dong3, Yi Du1, *, Wen-Jing Luo4, *   

  1. 1Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China; 2National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi Zhuang Autonomous Region, China; 3Department of Neurology, the People’s Hospital of Chuxiong Yi Autonomous Prefecture, Chuxiong Yi Autonomous Prefecture, Yunnan Province, China; 4Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
  • Online:2023-02-15 Published:2022-08-09
  • Contact: Wen-Jing Luo, MD, wenjingluo125@qq.com; Yi Du, MD, duyi@gxmu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81560162; and the Guangxi Natural Science Foundation of China, No. 2018GXNSFAA050052 (both YD).

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Abstract: Methylprednisolone pulse treatment is currently used for optic neuritis. It can speed visual recovery, but does not improve the ultimate visual outcomes. Recent studies have reported that miR-125a-5p has immunomodulatory effects on autoimmune diseases. However, it remains unclear whether miR-125a-5p has effects on optic neuritis. In this study, we used adeno-associated virus to overexpress or silence miR-125a-5p in mice. We found that silencing miR-125a-5p increased the latency of visual evoked potential and aggravated inflammation of the optic nerve. Overexpression of miR-125a-5p suppressed inflammation of the optic nerve, protected retinal ganglion cells, and increased the percentage of Treg cells. Our findings show that miR-125a-5p exhibits anti-inflammatory effects through promoting the differentiation of Treg cells.

Key words: aquaporin-4, corticosteroids, inflammation, microRNA, neuroprotection, oligodendrocyte, optic neuropathy, regulatory T cells, Th17 cell, visual field defect