Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (2): 324-.doi: 10.4103/1673-5374.346479

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Acid-sensing ion channel 1a: a novel target in Alzheimer’s disease?

Dalila Mango*, Robert Nisticò   

  1. School of Pharmacy, University of Rome “Tor Vergata”; Laboratory of Pharmacology of Synaptic Plasticity, European Brain Research Institute, Rome, Italy
  • Online:2023-02-15 Published:2022-08-06
  • Contact: Dalila Mango, PhD, d.mango@ebri.it.

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Abstract: Alzheimer’s disease (AD) represents the most common form of dementia and is characterized by a progressive decline of cognitive functions. Complex multifactorial processes underlie AD pathophysiology, including amyloid-beta (Aβ) toxicity, tau protein hyperphosphorylation, synaptic dysfunction, oxidative stress, and neuroinflammation (Ju and Tam, 2022).