Abstract: Lysophospholipids are metabolites of glycerophospholipids and sphingolipids that are commonly found as lipid constituents of cell membranes. In addition to their function as structural membrane components, certain members of the lysophospholipid family have considerable cell signaling properties. Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) represent the two major bioactive members of the lysophospholipid family that address specific G-protein coupled receptors, simply referred to as S1P (subtypes S1P1–5) and LPA (subtypes LPA1–6) receptors (Kano et al., 2022). Lysophospholipid signaling has a wide range of physiological functions and potential pathophysiological effects in the adult organism, but also plays important roles during embryonic development, especially in the development of the nervous, vascular and immune system (Kano et al., 2022).