Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (7): 1407-1408.doi: 10.4103/1673-5374.387988

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Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis

Naomi Hartopp, Andrea Markovinovic, Christopher CJ Miller, Patricia Gomez-Suaga*   

  1. Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK (Hartopp N)
    Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Markovinovic A, Miller CCJ)
    Universidad de Extremadura. Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain (Gomez-Suaga P)
    Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), Madrid, Spain (Gomez-Suaga P)
    Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain (Gomez-Suaga P)
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Patricia Gomez-Suaga, PhD, pgomezsuaga@unex.es.
  • Supported by:
    This work was supported by grants from the UK Medical Research Council (MR/R022666/1), Alzheimer’s Disease Society (AlzSoc-287) and Alzheimer’s Research UK (ARUK-PG2017B-3 and ARUK-DC2019-009) to CCJM, a Motor Neurone Disease Association Fellowship to PGS and a King’s College Guy’s and St Thomas’s studentship to NH. PGS is supported by an MSCA-Seal of Excellence-HEALTH fellowship (IHMC22/00025) from the Instituto de Salud Carlos III (ISCIII) and funded by the “Mecanismo para la Recuperación y la Resiliencia¨ (MRR) program from The NextGenerationEU funds (European Union) and by Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII) (CB06/05/0041).

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Abstract: Amyotrophic lateral sclerosis (ALS) is a fast-progressing fatal neurodegenerative disease and the most common form of motor neuron disease. There is currently no cure and approximately 90% of cases are sporadic. ALS shares genetic causes, clinical and neuropathological features with frontotemporal dementia, the second most common form of presenile dementia. ALS and frontotemporal dementia are therefore considered a disease spectrum (Abramzon et al., 2020). Various cellular disruptions contribute to disease pathogenesis making effective treatment via a single target challenging. Therapeutic interventions that modulate multiple cellular mechanisms may therefore be most effective in treating such complex diseases.