Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (8): 1639-1640.doi: 10.4103/1673-5374.389639

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MAP4K inhibition as a potential therapy for amyotrophic lateral sclerosis

Shuaipeng Ma, Chun-Li Zhang*   

  1. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA (Ma S, Zhang CL) 
    Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA (Ma S, Zhang CL)
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Chun-Li Zhang, PhD, Chun-Li.Zhang@UTSouthwestern.edu.
  • Supported by:
    CLZ is a W.W. Caruth, Jr. Scholar in Biomedical Research. This work was supported by the TARCC, Welch Foundation Award (I-1724), the Decherd Foundation, the Pape Adams Foundation, and NIH grants NS092616, NS127375, NS117065, and NS111776 (to CLZ).

Abstract: Amyotrophic lateral sclerosis (ALS) is a rare neurological disease, featuring gradual loss of muscle controls due to degeneration of motor neurons. Unfortunately, there is currently no cure for ALS. The available therapies only offer a limited extension of survival by several months, begging for more options of therapeutics.