Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (1): 322-323.doi: 10.4103/NRR.NRR-D-24-01125

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Potential treatment of Alzheimer’s disease astrocyte pathology based on nuclear lipid regulation

Masato Komai, Nobumasa Takasugi*   

  1. Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan
  • Online:2026-01-15 Published:2025-04-23
  • Contact: Nobumasa Takasugi, PhD, ntakasu@okayama-u.ac.jp.
  • Supported by:
    This work was supported by a grant from the Japan Foundation for applied enzymology (to NT), the Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (26430059, 17K08272, and 20K07014 to NT), the establishment of university fellowships toward the creation of science technology innovation (JPMJFS2128), and a Grant-in-Aid for JSPS Fellows (23KJ1603) (to MK).

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Abstract: The purpose of this perspective is to discuss the future development of a potential treatment of glial pathology in Alzheimer’s disease (AD) and a new regulatory mechanism, nuclear lipids, which may be involved in the pathogenesis of the disease, based on the work of the authors (Takasugi et al., 2011; Komai et al., 2024).