Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (7): 2948-2949.doi: 10.4103/NRR.NRR-D-25-00768

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Adult central nervous regeneration in Drosophila: Evidence for glial lineage conversion and neurogenic potential post-injury

Sergio Casas-Tintó*, Maria Losada-Pérez*   

  1. Instituto de Investigación de Enfermedades Raras, Instituto de Investigación Carlos III, Madrid, Spain
    Departamento de Biología Celular e Histología, Universidad Complutense de Madrid, Madrid, Spain
  • Online:2026-07-15 Published:2026-03-27
  • Contact: Maria Losada-Pérez, PhD, marilosa@ucm.es; Sergio Casas-Tintó, PhD, sergio.casas@isciii.es.
  • Supported by:
    This work was supported by MCIN/ AEI (Spanish Government), Grant No. PID2022-137751OA-00I (to MLP).

Abstract: Adult neurogenesis is generally considered to be very limited; however, there is increasing evidence that this phenomenon is conserved across species. Traditionally, research has focused on identifying precursor cells, those that are actively dividing or have the potential to divide. Direct evidence of adult neurogenesis has been found in rats, mice, songbirds, and nonhuman primates. In humans, while the evidence is indirect, it strongly suggests that neurogenesis also occurs during adulthood. In mammals, this active neurogenesis is preserved by radial glial progenitors, which remain in specific niches in the subventricular zone of the lateral ventricles and in the subgranular zone of the hippocampal dentate gyrus (Kumar et al., 2019).