Abstract: While acute nociceptive pain is a crucial warning system that protects us from injury or disease, chronic pain is not protective, but a pathological condition. As such, it is now recognized as a disease in its own right, which major classes refer to inflammatory, neuropathic, and idiopathic pain. It is frequent, with up to a third of the population that may suffer at one point from chronic pain. It is often associated with other pathologies, including sleep disorders, anxiety, depression, and is still difficult to treat. It thus represents a significant burden in terms of health and societal impact (Tracey et al., 2019). The mechanisms of chronic pain involve multiple diverse pathways in both the peripheral and central nervous systems (CNS), reflecting its multifaceted biology. Indeed, research over the past decades has established that central sensitization (enhancement in the function of neurons and circuits in central nociceptive pathways), in particular within the dorsal horn, the first central relay of nociceptive inputs plays a key role in the chronicity of pain (Latremoliere and Woolf, 2009).