Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (14): 1106-1112.

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Effects of cytokines and chemokines on   migration of mesenchymal stem cells following spinal cord injury

Longyun Li, Maoguang Yang, Chunxin Wang, Qiheng Zhao, Jian Liu, Chuanguo Zhan, Zhi Liu, Xuepeng Li, Weihua Wang, Xiaoyu Yang   

  1. Department of Orthopedics, China-Japan Friendship Hospital, Jilin University, Changchun 130033, Jilin Province, China
  • Received:2012-01-18 Revised:2012-03-20 Online:2012-05-15 Published:2012-05-15
  • Contact: Weihua Wang, M.D., Professor, Chief physician, Doctoral supervisor, Department of Orthopedics, China-Japan Friendship Hospital, Jilin University, Changchun 130033, Jilin Province, China; Xiaoyu Yang, Professor, Doctoral supervisor, Department of Orthopedics, China-Japan Friendship Hospital, Jilin University, Changchun 130033, Jilin Province, China yangxiaoyu88@sina.com
  • About author:Longyun Li☆, Studying for doctorate, Associate chief physician, Master’s supervisor, Department of Orthopedics, China-Japan Friendship Hospital, Jilin University, Changchun 130033, Jilin Province, China

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Abstract:

We investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the curative effects of mesenchymal stem cells. This study reviewed the effects of tumor necrosis factor-α, vascular endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor, basic fibroblast growth factor, insulin like growth factor-1, stromal cell-derived factor and monocyte chemoattractant protein-1, 3 during mesenchymal stem cell migration to damaged sites, and analyzed the signal transduction pathways involved in their effects on mesenchymal stem cell migration. The results confirmed that phosphatidylinositol 3-kinase/serine/threonine protein kinases and nuclear factor-κB play crucial roles in the migration of mesenchymal stem cells induced by cytokines and chemokines.

Key words: spinal cord injury, mesenchymal stem cells, migration, cytokine, chemokine, signaling pathway, neural regeneration