Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (2): 119-124.

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Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid

Fei Cao1, 2, Mantao Chen1, 2, Gu Li1, 2, Ke Ye1, 2, Xin Huang1, 2, Xiujue Zheng1, 2   

  • Received:2011-09-07 Revised:2011-11-22 Online:2012-01-15 Published:2012-01-15
  • Contact: 1 Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China 2 Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
  • About author:Fei Cao☆, Doctor, Attending physician, Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China

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Abstract:

The diffuse brain injury model was conducted in Sprague-Dawley rats, according to Marmarou’s free-fall attack. The water content in brain tissue, expression of metabotropic glutamate receptor 1α mRNA and protein were significantly increased after injury, reached a peak at 24 hours, and then gradually decreased. After treatment with the competitive antagonist of metabotropic glutamate receptor 1α, (RS)-1-aminoindan-1, 5-dicarboxylic acid, the water content of brain tissues decreased between 12-72 hours after injury, and neurological behaviors improved at 2 weeks. These experimental findings suggest that the 1-aminoindan-1, 5-dicarboxylic acid may result in marked neuroprotection against diffuse brain injury.

Key words: diffuse brain injury, in vivo, animal model, metabotropic glutamate receptor 1 alpha, 1-aminoindan-1, 5-dicarboxylic acid