Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (2): 131-135.

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Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine

Gang Yao1, 2, Yuhong Man1, Xiangdan Luo3, Tingmin Yu1, Lin Ji4   

  1. 1 Department of Neurology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
    2 Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
    3 Department of Food Science, College of Quartermaster Technology, Jilin University, Changchun 130000, Jilin Province, China
    4 Liaoyuan Vocational Technical and Medical College, Liaoyuan 136200, Jilin Province, China
  • Received:2011-09-06 Revised:2011-11-19 Online:2012-01-15 Published:2012-01-15
  • Contact: Tingmin Yu, Doctor, Professor, Master’s supervisor, Department of Neurology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China ytm_396@163.com
  • About author:Gang Yao☆, Studying for doctorate, Department of Neurology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China; Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China

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Abstract:

The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system.

Key words: proenkephalin, substance P, migraine, rizatriptan benzoate, midbrain, real-time quantitative polymerase chain reaction, pain