Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (2): 137-140.

Previous Articles     Next Articles

Calcium channel blockers and Alzheimer’s disease

Yi Tan, Yulin Deng, Hong Qing   

  1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China
  • Received:2011-07-08 Revised:2011-10-09 Online:2012-01-15 Published:2012-01-15
  • Contact: Hong Qing, Ph.D., Professor, School of Life Science, Beijing Institute of Technolo-gy, Beijing 100081, China hqing@bit.edu.cn
  • About author:Yi Tan★, Studying for mas-ter’s degree, School of Life Science, Beijing Institute of Technology, Beijing 100081, China

PDF

1142

Abstract:

Alzheimer’s disease is characterized by two pathological hallmarks: amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging. Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer’s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer’s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer’s disease therapy.

Key words: Alzheimer’s disease, calcium channel, calcium homeostasis, Alzheimer’s disease pathogenesis, β-amyloid, calcium channel blocker