Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (26): 2028-2035.

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Reduced information transmission in the internal segment of the globus pallidus of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced rhesus monkey models of Parkinson’s disease

Yan He1, Jue Wang1, Guodong Gao2, Guangjun Zhang1   

  1. 1 The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, National Engineering Research Center of Health Care and Medical Devices; Xi’an Jiaotong University Branch, Xi’an 710049, Shaanxi Province, China
    2 Department of Neurosurgery, Tangdu Hospital Affiliated to the Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China
  • Received:2012-05-29 Revised:2012-08-11 Online:2012-09-15 Published:2012-09-15
  • Contact: Jue Wang, Ph.D., Professor, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engi-neering, School of Life Science and Technology, Xi’an Jiaotong University, National Engineering Re-search Center of Health Care and Medical Devices; Xi’an Jiaotong University Branch, Xi’an 710049, Shaanxi Province, China juewang@mail.xjtu.edu.cn
  • About author:Yan He☆, Studying for doctorate, the Key Laborato-ry of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, National Engi-neering Research Center of Health Care and Medical Devices; Xi’an Jiaotong University Branch; Xi’an 710049, Shaanxi Province, China

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Abstract:

Rhesus monkey models of Parkinson’s disease were induced by injection of N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine. Neural firings were recorded using microelectrodes placed in the internal segment of the globus pallidus. The wavelets and power spectra show gradual power reduction during the disease process along with increased firing rates in the Parkinson’s disease state. Sin-gular values of coefficients decreased considerably during tremor-related activity as well as in the Parkinson’s disease state compared with normal signals, revealing that higher-frequency compo-nents weaken when Parkinson’s disease occurs. We speculate that the death of neurons could be reflected by irregular frequency spike trains, and that wavelet packet decomposition can effectively detect the degradation of neurons and the loss of information transmission in the neural circuitry.

Key words: neuronal oscillation, microelectrode, Parkinson’s disease, wavelet packet decomposition, singular value, neural regeneration