Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (8): 589-594.

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Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage

Baixiang He, Gang Bao, Shiwen Guo, Gaofeng Xu, Qi Li, Ning Wang   

  1. Department of Neurosurgery, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
  • Received:2011-12-20 Revised:2012-02-08 Online:2012-03-15 Published:2012-03-15
  • Contact: Baixiang He, Department of Neurosurgery, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China hbxsjwk@126.com
  • About author:Baixiang He★, Master, Chief physician, Department of Neurosurgery, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China

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Abstract:

Animal models of intracerebral hemorrhage were established by injection of autologous blood into the caudate nucleus in rats. Cell apoptosis was measured by flow cytometry and immunohistochemical staining of the p75 neurotrophin receptor. p75 neurotrophin receptor protein was detected by immunohistochemistry. p75 neurotrophin receptor mRNA was examined by quantitative real-time polymerase chain reactions. At 24 hours after modeling, cellular apoptosis occured around hematoma with upregulation of p75 neurotrophin receptor protein and mRNA was observed, which directly correlated to apoptosis. This observation indicated that p75 neurotrophin receptor upregulation was associated with cell apoptosis around hematomas after intracerebral hemorrhage.

Key words: intracerebral hemorrhage, apoptosis, p75 neurotrophin receptor, neural regeneration