Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (20): 1863-1871.doi: 10.3969/j.issn.1673-5374.2013.20.005

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Cell cycle-related genes p57kip2, Cdk5 and Spin in the pathogenesis of neural tube defects

Xinjun Li1, Zhong Yang2, Yi Zeng3, Hong Xu1, Hongli Li2, Yangyun Han1, Xiaodong Long1, Chao You4   

  1. 1 Department of Neurosurgery, Deyang People’s Hospital, Deyang 618000, Sichuan Province, China
    2 Department of Neurobiology, the Third Military Medical University of Chinese PLA, Chongqing 400038, China
    3 Department of Neurosurgery, Sichuan Provincial People’s Hospital, Chengdu 610041, Sichuan Province, China
    4 Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2012-06-07 Revised:2012-09-19 Online:2013-07-15 Published:2013-07-15
  • Contact: Hong Xu, Master, Chief physician, Department of Neurosurgery, Deyang People’s Hospital, Deyang 618000, Sichuan Province, China, jy988lxj @sina.com.
  • About author:Xinjun Li, Master, Attending physician.

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Abstract:

In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified several genes involved in the development of neural tube defects. In this study, we established a model of developmental neural tube defects by administration of retinoic acid to pregnant rats. Gene chip hybridization analysis showed that genes related to the cell cycle and apoptosis, signal transduction, transcription and translation regulation, energy and metabolism, heat shock, and matrix and cytoskeletal proteins were all involved in the formation of developmental neural tube defects. Among these, cell cycle-related genes were predominant. Retinoic acid treat-ment caused differential expression of three cell cycle-related genes p57kip2, Cdk5 and Spin, the expression levels of which were downregulated by retinoic acid and upregulated during normal neural tube formation. The results of this study indicate that cell cycle-related genes play an im-portant role in the formation of neural tube defects. P57kip2, Cdk5 and Spin may be critical genes in the pathogenesis of neural tube defects.